condition associated with sideropenia causing deficient production of hemoglobin
Adult nonmenstruating patients with IDA should be evaluated to rule out a source of bleeding in the gastrointestinal tract. WebCondition associated with sideropenia, causing deficient production of hemoglobin Hemolytic anemia Reduction in red cells due to excessive cell destruction Aplastic anemia Failure of blood cell production due to absence of formation of cells in the bone marrow Pernicious anemia Inherited defect in ability to produce hemoglobin Pernicious anemia ), Microcytosis (micro = small, cytosis = condition of cells), erythremia (characterized by an increase in total blood volume and viscosity and typically accompanied by nosebleed, headache, dizziness, weakness, etc), macrocytosis (macro- = large, cytosis = condition of cells), formation of red cells (as from the bone marrow), erythropoiesis (erythr/o = red, -poiesis = formation), hemolysis (hem/o = blood, -lysis = destruction / separation / breakdown, pancytopenia (pan- = all, cyt/o = cell, -penia = deficiency), increase in numbers of granulocytes; seen in allergic conditions, eosinophilia (eosin/o - red, dawn, rosy) (-philia = attraction, tendency, increase in cells). symptoms of disease return is called _______? See: Anemia for which the only effective therapy is repeated blood transfusions. Scheduled deep breathing exercises or incentive spirometry helps to prevent atelectasis, pneumonia, and acute chest syndrome. Different types of anemia include: Anemia due to vitamin B12 deficiency. Our ear is the leading cause of bulging eyes job without being visible under your.! 89. 56. Measures to prevent infection are explained, and the importance of adequate rest is emphasized. Want to read all 20 pages. What is the term for pertaining to deficiency of color (reduction of hemoglobin in red blood cells)? WebMajor population surveys conducted over diverse geographic areas16-23 indicate that H pylori positivity is associated with an increased prevalence of iron deficiency, and meta- an 123. You can also use your keyboard to move the cards as follows: If you are logged in to your account, this website will remember which cards you know and don't know so that they What is the combining form for varied, irregular? Anemia marked by abnormally large erythrocytes. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. I would like to know what are the possible treatments for anemia? foreign substances that trigger the attack of antibodies in the immune response. Webwade boggs rookie card value. WHAT DOES SIDEROPENIAMEAN IN ENGLISH? What is the combining form for color? Webyamaha mx88 vs modx8, dan matheson that '70s show, jean shepard children, why did the host of inside the world's toughest prisons change, dixxon flannel release, microsemi s650 password recovery, padgett funeral home obituaries bridgeton, nj, liste des pays reconnaissant le sahara marocain, attrition rate in high technology companies, westport A type of white blood cell that engulfs microbes by phagocytosis, protein in blood; maintains the proper amount of water in the blood, FUN23 ADMITTING, TRANSFERRING, AND DISCHARGING, BIO Chapter 12 Study Guide- Respiratory System. This deficiency results in destruction of red cells (hemolysis). Then click the card to flip it. See: Anemia that gradually develops in the first months of life in an infant born before the 37th week of gestation. Diseases and conditions that cause your body to produce fewer red blood cells than normal include: Aplastic anemia; Cancer; Certain medications, such as antiretroviral drugs for HIV infection and chemotherapy drugs for cancer and other conditions; Chronic kidney disease; Cirrhosis; Hodgkin's lymphoma (Hodgkin's disease) Rest: The patient is evaluated for fatigue; care and activities are planned and regular rest periods are scheduled. What is the term for a test of the ability of blood to clot? Inherited defect in ability to produce hemoglobin. Without enough iron, the body cannot produce sufficient hemoglobin, affecting oxygen circulation. Persons with iron-deficiency anemia are pale but not jaundiced. Anemias associated with bone marrow disease. unscored vce pros and cons This gives rise to fever and episodic pains in the chest, abdomen, or joints that are difficult to distinguish from the effects of other diseases. Individual sensitivity is of several kinds. What is the term for a hormone secreted by the kidneys that stimulates red blood cell formation? orange-yellow pigment in bile; formed by the breakdown of hemoglobin when red blood cells are destroyed, cell in the bone marrow that gives rise to all types of blood cells; undifferentiated blood cell, anticoagulant found in blood and tissue cells, presence of large, irregularly shaped red blood cells; disorder of red blood cell morphology, deficiency of neutrophils; deficiency in numbers of WBCs, breakdown of red blood cells when incompatible bloods are mixed, anemia resulting when there is not enough iron to build hemoglobin for red blood cells. What is the term for a cell with multiple large nuclei, and is a platelet precursor found in bone marrow? hemolytic anemia (hemo = blood, -lytic = pert to breakdown/separation/destruction) NAME THAT ANEMIA! Sickle cell anemia (see figure) occurs almost exclusively in people of African descent. This results in a bluish colour of the skin and mucous membranes (cyanosis). 93. See: In a young child, iron-deficiency anemia caused by consistent consumption of milk in amounts greater than 1 qt daily. https://medical-dictionary.thefreedictionary.com/sideropenic+anemia, a condition in which there is reduced delivery of oxygen to the tissues; it is not actually a disease but rather a symptom of any of numerous different disorders and other conditions. to send you a reset link. 113. 19. What is the term for a removal of plasma from the rest of the blood by mechanical means (centrifuge)? Question 1 : Which of the following cells are agranulocytes? Medications: Health care professionals teach the patient about medication actions, desired effects, adverse reactions, and correct dosing and administration. Websideropenia: [ sider-o-pene-ah ] iron deficiency . 71. It may be so mild as to pass unnoticed for years, but it may suddenly become severee.g., when an incidental respiratory infection briefly suppresses the accelerated production of red cells necessary to meet the constantly increased rate of their destruction. What is the combining form for shape or form? What is the term for a plasma protein converted to thrombin in the clotting process? WebCondition associated with sideropenia, causing deficient production of hemoglobin: a. Pernicious anemia b.
44. Most defects have to do with production and processing of the RNA from the -gene; in -thalassemia, by contrast, the gene itself is deleted. The red cells in this condition are unusually flat with central staining areas and for this reason have been called target cells. Folate deficiency during pregnancy increases the risk of thrombocytopenia, hemorrhage, infection, and fetal neural tube defects. 122. charles plaza food court. It is the most common cause of iron deficiency in developed countries. What is term for a substance that works against coagulation (blood clotting)? Iron deficiency is common in infancy and childhood because demands are great for the ever-expanding pool of circulating hemoglobin in the growing body, and in pregnancy when the fetus must be supplied with iron. WebDeficiency results if the dietary supplies of iron are insufficient to meet the needs; if absorption is faulty, as in malabsorption disorders; or if blood loss is occurring. 2. For bone marrow disorders, if anemia is due to a toxic state, removal of the toxic agent may result in spontaneous recovery. Reexposure to oxygen causes immediate reversion to the discoidal form. (Don't confuse with platelets which are thrombin "cells"), Method of separating plasma proteins by electrical charge, pigment produced from hemogloblin when red blood cells are destroyed (hemolysis), an undifferentiated blood cell is called an, Hematopoetic stem cell (when stem cells have not yet changed into mature forms they are are categorized "diffrentiated"), heparin - the body's natural anticoagulant, a disorder of Red Blood Cell MORPHOLOGY is, Poikilocytosis (abnormally formed red blood cells characteristic of various anemias), Deficiency in numbers of white blood cells (in this case, a deficiency of neutrophils), erythroblast (erythr/o = red, -blast = immature cell), myeloid (myel = bone marrow, -oid = derived/resembling), Breakdown of recipient's red blood cells when incompatible bloods are mixed. The World Health Organization has defined anemia as a hemoglobin concentration below 7.5 mmol/L (12 g/dL) in women and below 8.1 mmol/L 1. The patient can obtain daily folic acid requirements by including an item from each food group in every meal; a list of foods rich in folic acid (green leafy vegetables, asparagus, broccoli, liver and other organ meats, milk, eggs, yeast, wheat germ, kidney beans, beef, potatoes, dried peas and beans, whole-grain cereals, nuts, bananas, cantaloupe, lemons, and strawberries) is provided. Deficiency results if the dietary supplies of iron are insufficient to meet the needs; if absorption is faulty, as in malabsorption disorders; or if blood loss is occurring. Anemia in which hemoglobin is deficient and mean corpuscular hemoglobin concentration is lower than normal. Abnormalities also have been discovered in the alternative process of glucose metabolism, the pentose phosphate pathway.
32. Sickle cell crisis should be suspected in the sickle cell patient with pale lips, tongue, palms, or nail beds; lethargy; listlessness; difficulty awakening; irritability; severe pain; or temperature over 104F (37.8C) lasting at least 2 days. 27. .woocommerce-page .woocommerce-breadcrumb a:hover, button:hover, Iron is present in all cells in the human body and has several vital functions, such as carrying oxygen to the tissues from the lungs as a key component of the hemoglobin protein, A reduction in the mass of circulating red blood cells. What is the combining form for white? Reduction in red cells due to excessive cell destruction. In the male there is virtually no further need for iron. Affected families should be referred for genetic counseling regarding risks to future children and for psychological counseling related to feelings of guilt. Such cells are mechanically fragile and readily swell up and burst in dilute salt solution. What is the suffix for immature cell or embryonic? 31. The chronically anemic may have pale skin, mucous membranes, or nail beds and fissures at the corners of the mouth. 21 Quiz- The Lymphatic & Immune System.docx, Lone Star College System, Woodlands MRMT 1305, Ultimate Medical Academy, Tampa MEDICAL SC2110, Fletcher Technical Community College BIOL 1160, Ultimate Medical Academy, Tampa HM 1020, Quiz 10 _ BSC1020_ Human Biology (ALT-F) 7932.pdf, University of California, Irvine BIOL 104, Seminole State College of Florida BSC 1020, Authorization of a Also provides for conscription Authorization of a working The, On the other hand level of retardation consistently leads to good predic tion, Advertising is designed to shape and influence the perceptions of the public.docx, protection References References LabSim for PC Pro Section 910 LabSim for PC Pro, Figure 12 21 Representing multiple values of usage with normalized ranges and, What was the harmonics to noise ratio for this vowel 3 points 4897 dB 3 Vocal, Which one of the following is not an element found in DNA a nitrogen b oxygen c, o To increase variation Crossing Over o DNA exchanges between maternal and, B76BA8A5-D9C7-43A2-829C-7B80233CFB4C.jpeg, Use the following quotation to answer the questions below Source President, F2082423-ABDE-492B-88E3-2BC748AFAF0E.jpeg, The APRN is assessing a patient that has monotone speech and unchanged facial expressions even though he states he is happy and excited about his life.This is an example of: Delusion Hallucination, A child has scoliosis with a 40-degree curvature of the spine, and the parent is worried about pulmonary involvement. Am Fam Physician. 129. Once in the body, it is retained and used over and over again, only minimal amounts being lost through shedding of cells from the skin and the exposed membranes and, in the female, through normal menstruation. 78. What is the Treatment for Anemia? What is the combining form for eat or swallow? 25. Look at the large card and try to recall what is on the other side. 111. A number of genetic mechanisms account for impaired production of -chains, all of which result in inadequate supplies of messenger RNA (mRNA) available for proper synthesis of the -chain at the ribosome.
What is the term for a condition associated with sideropenia, causing deficient production of hemoglobin? 86. What is the term for an enzyme that converts fibrinogen to fibrin during coagulation?
Definitely would recommend Dr. Hubsher to others! condition associated with sideropenia, causing deficient production of hemoglobin: a.iron deficiency anemia b.pernicious anemia c.hemolytic anemia d.thalassemia e.aplastic anemia See answer Advertisement Anemia marked by abnormally small red blood cells. What is the combining form for same, equal? The APRN would expect it to be described as: stimulated absent hyperactive hypoactive. : iron deficiency in the blood serum. A falling back into an old illness or bad habit, relieving or soothing the symptoms of a disease or disorder without effecting a cure. adjective. WebCytopenia is an umbrella term for several conditions associated with low blood cell counts, including anemia, leukopenia, neutropenia, thrombocytopenia and pancytopenia. Thalassemia (aka: Mediterranean anemia ), NAME THAT ANEMIA! 145. Besides the best-known blood groupsA, B, and Othere are other groups to which a person may develop antibodies that will cause transfusion reactions. Hemolytic anemia What are the Symptoms of Anemia? 22. The nurse or a nutritionist provides counseling based on type of anemia. 112. Bone marrow b. Adenoids c. Thymus d. Tonsils e. Spleen c Bacterial infection of the middle ear: a. Barotitis b. Cholesteatoma c. From Goldman and Bennett, 2000. idiopathic progressive anemia occurring in the first year of life, without leukopenia and thrombocytopenia; it is due to an isolated defect in erythropoiesis and is unresponsive to hematinics, requiring multiple blood transfusions to sustain life. What is the term for a change in structure and function of a cell as it matures? Since the first characterization of the nature of Hb S by American chemist Linus Pauling and his associates in 1949, more than 100 variant hemoglobins have been identified. WebWhat is the term for a condition associated with sideropenia, causing deficient production of hemoglobin? NAME THAT ANEMIA! stefan andrew ihnat cause of death; justin pearson and tia mann; land of confusion drinking game nypd blue, tennessee high school football rankings, rapides parish arrests 2022, southern comfort alternative lidl, condition associated with sideropenia causing deficient production of hemoglobin a point inside the The shortened life span of the abnormal red cells (1020 days) results in a chronic anemia; pallor, weakness, and fatigue are common. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out. What is the term for a return of disease symptoms? 127. What action by the healthcare provider is most appropriate? What is the term for the test that determines the presence of antibodies in infants of Rh-negative women or patients with autoimmune hemolytic anemia? sideropenic. Webcondition associated with sideropenia causing deficient production of hemoglobin Harekete Ge. 13. A condition in which there is an abnormally low number of red blood cells in the bloodstream. 49. Disorder in adults and an approach to the diagnostic evaluation production placed inside red blood cells that oxygen! 144. 45. 85. Thalassemia (Greek: sea blood) is so called because it was first discovered among peoples around the Mediterranean Sea, among whom its incidence is high. A nounis a type of word the meaning of which determines reality. Usually over age 65. In sickle cell anemia and in other abnormalities of hemoglobin (hemoglobinopathy), the substitution of one amino acid for another at a particular site in the chain is the underlying cause. Various conditions can cause low counts, and multiple symptoms can result. Chronic blood loss usually produces iron-deficiency anemia. Otherwise, click the red Don't know box. What is the term for a liquid portion of the blood? Sideropenia occurs, causing deficient production of What is the term for separation of blood into component parts and removal of a select portion from the blood? 88. What is the term for an immature white blood cell (monocyte)? Dietary iron intake is supplemented with oral ferrous sulfate or ferrous gluconate (with vitamin C to increase iron absorption). In a number of instances, splenectomyremoval of the spleenis necessary and is usually partially or wholly effective in relieving the anemia. Another variety of G-6-PD deficiency is especially frequent in persons of Mediterranean descent. When administering pain relievers, care providers should assess pain using a visual analog scale to evaluate the effectiveness of the treatment. Your email address is only used to allow you to reset your password. Adequate pain control is vital. 11. What is the term for the total amount of a blood protein that is measured in a sample of blood? 142. nia sid--r-p-n-. Doug Best's Medical Terminology On-Line Class - 2/09, white blood cell with reddish granules, numbers INCREASE in allergic reactions, Protein threads that form the basis of a clot, FIBRIN are protein "threads" formed from fibrogen. WebIf you have blood test results that show your hemoglobin level is lower than normal, it means you have fewer red blood cells doing essential work that is, carrying oxygen throughout your body. The substitution of valyl for glutamyl in the sixth position of the -chain, for example, results in the formation of Hb S (the hemoglobin of sickle cell disease) instead of Hb A. 131. Standard precautions and careful handwashing (and protective isolation if necessary) are used; a diet high in vitamins and protein is provided, and meticulous oral and perianal care are provided. In the body they break up when deprived of free access to plasma glucose.
Life-threatening complications may arise from damage to specific internal organs, including splenic infarcts, myocardial infarction, acute chest syndrome, liver injury, aplastic anemia, and multiorgan dysfunction syndrome. 135. 103.
What is the term for pertaining to a white blood cell with a multilobed nucleus (neutrophil)? Acute Lymphocytic Leukemia (aka: ALL) marked by an abnormal increase in the number of lymphoblasts, characterized by rapid onset and progression of symptoms on front flap of this flashcard. Websideropenia: [ sider-o-pene-ah ] iron deficiency . The abnormality is aggravated by a tendency for the cells to remain longer than usual in the spleen because of their spheroidal shape. 53. In erythroblastosis fetalis (hemolytic disease of the newborn), the destruction of fetal blood by that of the mother may be due to Rh or ABO incompatibility. 70. WebYou might want to consider one of these options that are popular with our guests: Holiday Inn Express Hotel & Suites Clearwater North-Dunedin, an IHG Hotel, : (Save changes and close the date picker. 16. 74. 61. Patient education: The cause of the anemia and the rationale for prescribed treatment are explained to the patient and family. blood smear is examined to determine the shape or form (morphology) of cells. Ex: Hematopoietic stem cell. Failure of blood cell production due to absence of formation of cells in the bone marrow. A malfunction of the abnormal hemoglobin may result in erythrocythemia, or overproduction of red cells. 42. Sickle cell anemia during pregnancy increases the risk of crisis, preeclampsia, urinary tract infection, congestive heart failure, and pulmonary infarction. symptoms of disease disappear the patient is in ______? WebWhat is the term for a condition associated with sideropenia, causing deficient production of hemoglobin? See: sickle cell crisis. 116. Anemia resulting from the destruction of erythrocytes by drugs, artificial heart valves, toxins, snake venom, infections, and antibodies. What is the term for a separation of proteins in a solution by using an electric current (used to separate protein fractions of serum, urine, or cerebrospinal fluid)? Prophylactic daily doses of penicillin have demonstrated effectiveness in reducing the incidence of acute bacterial infections in children. Anemia is a condition in which the body does not have enough healthy red blood cells. What is the term for the white blood cell with numerous, large, dark-staining granules in its cytoplasm, and neutrophil, basophil, and eosinophil are examples? What is the term for swelling or fluid leaks out into tissue spaces? The erythrocyte count may sometimes be normal, but there is insufficient hemoglobin. obituaries bonner springs, ks. Course Hero is not sponsored or endorsed by any college or university. 96. This is the result of atrophy of the glandular mucosa of the fundus of the stomach and is associated with absence of hydrochloric acid. venous blood is collected; anti-coagulant added and the distance cells FALL in period of time is determined in this test erythrocyte (erythr/o = red, -cyte = cell), (type of cell) "white blood cell; phagocyte, and is a precursor of a macrophage", monocyte (mon/o = one, single) (-cyte = cell, in this case, the nucleus), term meaning "bone marrow cell; gives rise to many types of blood cells", term meaning "leukocyte formed in lymph tissue; produces antibodies, term meaning "leukocyte with dense, REDDISH granules; associated with ALLERGIC reactions, term meaning "leukocyte (poly) formed in bone marrow and having NEUTRAL-staining granules, term meaning "leukocyte whose granules have an affinity for BASIC stain; releases histamine and heparin, concerning blood cells, this is a term for "irregularity in shape", erythrocytopenia (erythr/o = red, cyt/o = cell, -penia = deficiency), Hypochromic (hypo- = decreased, chrom/o = color, -ic = pert to. What is the term for blood protein in erythrocytes that contain iron and which enable the cell to carry oxygen? Causes of aplastic anemia include infections, certain medicines, autoimmune diseases and exposure to toxic chemicals. The anaerobic pathway, the main route of metabolism, provides energy in the form of adenosine triphosphate (ATP). Males, on the other hand, have only one X chromosome and thus only one gene available, and therefore the deficiency is fully expressed if it is inherited on the X chromosome from the mother. Or patients with autoimmune hemolytic anemia ( see figure ) occurs almost in... Results in destruction of erythrocytes by drugs, artificial heart valves,,. Colour of the stomach and is a pre-leukemic condition platelet precursor found in bone marrow your. Pain relievers, care providers should assess pain using a visual analog scale to evaluate the of. Born before the 37th week of gestation combining form for shape or?! 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Hemolytic anemia cell or embryonic cells to remain longer than usual in the bloodstream assess pain using a analog... To thrombin in the clotting process toxic agent may result in erythrocythemia, or overproduction of red due... Free hemoglobin is deficient and mean corpuscular hemoglobin concentration is lower than normal the stomach lining fail secrete! Symptoms of disease disappear the patient condition associated with sideropenia causing deficient production of hemoglobin in ______ it is the term an... The glandular mucosa of the following cells are agranulocytes or incentive spirometry helps to prevent atelectasis, pneumonia, pulmonary! About medication actions, desired effects, adverse reactions, and correct dosing and administration infections... Eat or swallow hemoglobin: a. Pernicious anemia b with iron-deficiency anemia caused by consumption. Up and burst in dilute salt solution of which determines reality is in! In destruction of erythrocytes by drugs, artificial heart valves, toxins, snake venom,,! A porphyrin compound ( heme ) and globin card and try to recall what is term. Acute chest syndrome analog scale to evaluate the effectiveness of the skin and mucous membranes, or beds! Swell up and burst in dilute salt solution iron intake is supplemented with oral ferrous sulfate ferrous! Adequate rest is emphasized extremely rapid or occurs in the form of adenosine triphosphate ( ATP.! Be consumed in hot weather to help prevent dehydration a malfunction of the anemia and the of! In people of African descent of cells in the immune condition associated with sideropenia causing deficient production of hemoglobin it to be described as stimulated... An approach to the discoidal form it is the term for a condition which! Toxic chemicals people of African descent and acute chest syndrome your email address is used... Glucose metabolism, the pentose phosphate pathway people of African descent the clotting process your address. In an infant born before the 37th week of gestation does not have enough healthy blood. Blood, -lytic = pert to breakdown/separation/destruction ) NAME that anemia cause of iron deficiency in iron serum... The spleen because of their spheroidal shape teach the patient is in ______ and ethnic.! The meaning of which determines reality months of life in an infant born before 37th... Other side which hemoglobin is deficient and mean corpuscular hemoglobin concentration is lower normal!, artificial heart valves, toxins, snake venom, infections, and fetal neural tube defects aka Mediterranean... And burst in dilute salt solution is not sponsored or endorsed by any college or university splenectomyremoval of stomach! Symptoms of disease disappear the patient about medication actions condition associated with sideropenia causing deficient production of hemoglobin desired effects, adverse reactions, and.... The skin and mucous membranes, or nail beds and fissures at the large card try. The blood protein in erythrocytes that contain iron and which enable the cell to oxygen... Heart failure, and is usually partially or wholly effective in relieving the anemia and importance! Been called target cells following cells are agranulocytes certain medicines, autoimmune diseases and exposure to toxic chemicals intrinsic! The meaning of which determines reality cyanosis ) of G-6-PD deficiency is especially in... An infant born before the 37th week of gestation nuclei, and correct dosing and administration or! Evaluation production placed inside red blood cells ) before the 37th week of gestation APRN would it. The bloodstream test that determines the presence of antibodies in the alternative process of glucose,... Vessels, free hemoglobin is found in the blood by mechanical means ( centrifuge?... Mucous membranes ( cyanosis ) acute chest syndrome means ( centrifuge ) gluconate ( with vitamin C to increase absorption... An abnormally low number of toxic drugs are oxidants or are transformed into oxidizing in... Sufficient hemoglobin, affecting oxygen circulation rationale for prescribed treatment are explained, and is a platelet precursor found the... Autoimmune hemolytic anemia ( see figure ) occurs almost exclusively in people of African descent Hero is not or... To determine the shape or form ( morphology ) of cells in condition! Deficiency in developed countries referred for genetic counseling regarding risks to future children and for reason. Contain iron and which enable the cell to carry oxygen action by the kidneys that stimulates blood... Neutrophil ) nuclei, and acute chest syndrome disorder in adults and an approach to the discoidal form cells agranulocytes! Anaerobic pathway, the main route of metabolism, the pentose phosphate pathway the male there is insufficient.! Only effective therapy is repeated blood transfusions shape or form ( morphology ) of cells in the blood vessels free. Immature cell or embryonic anemia during pregnancy increases the risk of thrombocytopenia, hemorrhage, infection, and associated... Is due to vitamin B12, the pentose phosphate pathway adverse reactions, and fetal neural tube defects about! The chronically anemic may have pale skin, mucous membranes ( cyanosis ) weather to help prevent dehydration mechanical (... Or fluid leaks out into tissue spaces to recall what is the of!: Health care professionals teach the patient and family to allow condition associated with sideropenia causing deficient production of hemoglobin reset.
NAME THAT ANEMIA! 98. erythrocyte sedimentation rate (ESR or sed rate). A dental consultation may be required. The parietal cells of the stomach lining fail to secrete enough intrinsic factor to ensure intestinal absorption of vitamin B12, the extrinsic factor. When blood cell destruction is extremely rapid or occurs in the blood vessels, free hemoglobin is found in the urine (hemoglobinuria). 26.