WebKarik and co-collaborator Drew Weissman, MD, PhD, invented the modified mRNA technology used in Pfizer-BioNTech and Modernas vaccines to prevent COVID-19 infection. Recently, Malonepublicly vilified and threatened legal action against another physician who reported his vaccine misinformation campaign to the Maryland Board of Physicians,and accused the Centers for Disease Control and Prevention of scientific fraud. Evolution of complexity in non-viral oligonucleotide delivery systems: from gymnotic delivery through bioconjugates to biomimetic nanoparticles. His mother was a dental hygienist. Together, they publish their results. Pierre Meulien, a molecular biologist who runs the European Union's Innovative Medicines Initiative, said that in 1993 he and his team were the first "to demonstrate that you could induce an immune response with mRNA." [20], In November 2021, Malone shared a deceptive video on Twitter that falsely linked athlete deaths to COVID-19 vaccines. Moderna suing Pfizer suggests her post doctoral research will be ignored in legal arguments about intellectual property since U. Penn. The mRNA is typically packaged inside a lipid nanoparticle, which keeps the delicate cargo intact until it reaches its final destination. By that point, Malone had long moved away from the field of mRNA vaccine development. It does not hang around in the body for a long time. What true heros these two scientists are! Malone deleted the video from his Twitter account after receiving a cease-and-desist letter from West's family. 2022 Dec 24;11(1):40. doi: 10.3390/vaccines11010040. And Columbia University awarded them the Louisa Gross Horwitz Prize, bestowed annually for groundbreaking work in medical science. Malone's celebrity as a vocal vaccine opponent, already many months in the making, skyrocketed to stratospheric proportions in December thanks to Rogan, the former "Fear Factor" host who's become one of the most popular podcasters. Yes, Dr. Malone did investigate work very early on before almost anyone else had with mRNA, like almost any discovery of almost anything, it takes a team to come up with final solutions. technology is destroying us. Although mRNA is of decisive importance to our understanding of gene function, no Nobel Prize was awarded for its discovery. Statistics or facts must include a citation or a link to the citation. 8600 Rockville Pike They grew sick, and some died. Now hes spreading unfounded claims about the vaccines and the virus. The messenger RNA is more so, somewhat an equalizer, mRNA is cheap to make, very quick," Dr. Karik told News 4. Not only have the new mRNA vaccines proven to be more effective and safer than traditional vaccines, they can be developed and reengineered to take on emerging pathogens and new variants with breathtaking speed. Later, when this is talked about, make scientist leads entire article, female scientist becomes footnote. (Kory is one of the most prominent voices advocating more ivermectin prescriptions.). [3][20][21] In April 2022, Davey Alba, writing for The New York Times, said that "[w]hile he was involved in some early research into the technology, his role in its creation was minimal at best", citing "half a dozen Covid experts and researchers, including three who worked closely with Dr. Dr. Malone worked on methods to more effectively deliver naturally occuring RNA and mRNA through the cell membrane using lipids (paper from 1989). But once the novel coronavirus was discovered and sequenced in Wuhan, China, everything changed, nearly overnight. WebThe concept of mRNA was developed by Sydney Brenner and Francis Crick in 1960 during a conversation with Franois Jacob. The United States is absolutely ridiculous in how theyve handled this vaccine and the pandemic itself. The mRNA set off a harmful inflammatory immune response in the mice. I am wondering whether or not Dr. Weissman is continuing to work with Ms. Kariko ? To reveal the dynamic m 6 A landscape of mRNA during maternal-to-zygotic transition (MZT) in mice, we used a recently developed SLIM-seq strategy (Fig. FULL CLAIM: Dr. Dr. Karik stated that many many scientists, not Malone, played a role in developing mRNA technology that went/go into the COVID injections and result in the The researchers braced for the shock waves their study would generate in the scientific community. Messenger RNA, or mRNA, is genetic material that tells your body how to make proteins. The existing treatment is a labor-intensive procedure that involves removing bone marrow from the patient, treating it with an altered virus designed to deliver a healthy version of the sickle cell gene, and then putting the marrow back into the patient. Boston University moderates comments to facilitate an informed, substantive, civil conversation. He's become a trusted source for people everywhere who aren't quite sure about these mRNA vaccines or whether they are really safe. From nerves and hormones to bacteria in the stomach; Nobel prize for achievements in gastrology during last century. "Oftentimes, I have no idea what I'm going to talk about until I sit down and talk to people," he said recently. Still, vaccine research and development doesn't end with the first doses in arms. Copyright 2015 Elsevier Ltd. All rights reserved. No testing on primates? I hope that puts thing into perspective. I had wanted to know. A shot of specially coded mRNA would instruct certain cells to manufacture the notorious COVID-19 spike protein, enabling the cells to briefly masquerade as the virus and teach the immune system to recognize it. Crdito: David Maris. Coronaviruses, like the one that causes COVID-19, are named for the crown-like spikes on their surface, called spike proteins. Dr. Malones ego keeps getting in the way of any praise that he should deservingly receive. [31] The publisher rejected the ivermectin paper due to what it stated were "a series of strong, unsupported claims" which they determined did "not offer an objective nor balanced scientific contribution. Karik and Weissman first met in 1998 over a photocopier while the two were reviewing science journals at the University of Pennsylvania. Karik, now 65, oversees mRNA protein replacement at BioNTech, a German biotech firm that developed a coronavirus vaccine in partnership with US pharma giant Pfizer. (Both Moderna's and Pfizer's vaccines are fully approved for adults by the FDA, and the military has a long history of requiring many vaccinesto protect US forces from disease.). His early work focused on mRNA technology,[3] pharmaceuticals, and drug repurposing research. Dr. Malone rightfully earned the title of Inventor of mRNA Vaccine Technology per Dr. Malones website where he lists his major publications and patents contributing to the invention of mRNA Vaccine Technology (which is nanotechnology) including Dr. Malones 1989 publication, Cationic Liposome Mediated RNA Transfection. Agree 100% Society is all part of the testing.This makes me wonder why they are hunting and blaming those who choose not to be vaccinated.It feels like a bad Sci Fi movie when I see these witch hunts in the media.This scares me more than anything I have been watching for the last 2 years. The timeline: A vaccine in under a year. [7] In December 2022, Malone was reinstated on Twitter as a result of Elon Musk's revision of the site's COVID disinformation policy. Hannah Yoon By Gina Kolata Published April 8, Earlier this year, Brandeis University and the Rosenstiel Foundation honored the scientists with the Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research. Ive always enjoyed working in my lab alone without much attention. In time, he believes mRNA gene therapies can bring hope to research on devastating neurological diseases such as Alzheimers and Parkinsons that have seen disappointingly few advances. Pierre Meulien, a molecular biologist who runs the European Union's Innovative Medicines Initiative, said that in 1993 he and his team were the first "to She tells him about mRNA, touting its vast potential. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). The people who manufacture, test and control these vaccines have worked (and are still working) massive number of hours (holidays & weekends included) to keep the facilities running 24 x 7. Weissman injected it into mice. The interests of power have leveraged it into something inhumane and destructive. This is key to overall effectiveness. If you are exposed to the real virus later, your body will recognize it and know how to fight it off. For these companies to make the product at their fully-controlled facilities and distribute them throughout the world is much more efficient, safer for patient and faster than sharing the formula. Last modified on Mon 23 Nov 2020 10.12 EST The Hungarian-born biochemist who helped pioneer the research behind the mRNA technology used in the Dr. Weissman said the mRNA trend is unstoppable and has taken over biotechnology, pharmaceuticals and academic laboratories worldwide that, as he described, previously had no interest in the matter. See https://pubmed.ncbi.nlm.nih.gov/16111635/ for Kariko and Weissmans original article in 2005 where Katalin Kariko is the lead author. We knew from the beginning that what we were doing had huge potential, he says, but every scientists work isnt like that. You cant give something that makes people sick.. [43] In July 2022, Malone, along with two other doctors, filed a lawsuit against Twitter for suspending their accounts, alleging a "breach of contract. Dr. Weissman, a physician and researcher at Penn Medicine, directs a variety of projects including a pan-coronavirus vaccine to prevent the next COVID epidemic. It's still unclear whether famotidine does much for COVID-19 patients. In 2018, the U.S. Food and Drug Administration (FDA) approved one of the very first RNA-mechanism drugs. Accessibility Epub 2022 Nov 10. Meanwhile, biotech companies like Moderna and BioNTech are charging forward on a mind-bending spectrum of mRNA applications, including personalized cancer vaccines and autoimmune therapies. Recent Advances in Lipid Nanoparticles for Delivery of mRNA. ", "Twitter ends Covid misinformation policy under Musk", https://www.linkedin.com/pulse/history-how-mrna-vaccines-were-discovered-jill-glasspool-malone-phd, "The original invention of the use of mRNA for drugs and vaccines", "The Malone Doctrine Health Conference Ireland", https://en.wikipedia.org/w/index.php?title=Robert_W._Malone&oldid=1144134349, CS1 Chinese (Hong Kong)-language sources (zh-hk), Short description is different from Wikidata, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 12 March 2023, at 00:57. One day, while waiting at the office to photocopy articles from a research journal, Weissman struck up a conversation with Penn biochemist Karik. There have been three coronavirus epidemics in the past 20 years, he explains. Allrightsreserved. Rogan's podcasting strategy is unabashedly ill-informed. Dr. Malone rightfully earned the title of Inventor of mRNA Vaccine Technology per Dr. Malones website where he lists his major publications and patents contributing to the invention of mRNA Vaccine Technology (which is nanotechnology) including Dr. Malones 1989 publication, Cationic Liposome Mediated RNA Transfection.

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Karik said in acceptance! Mrna is of decisive importance to our understanding of gene function, no Nobel Prize was awarded for discovery... Prize for achievements in gastrology during last century drug repurposing research in 1998 over a photocopier while the two also... Your collection due to an error his Twitter account after receiving a cease-and-desist letter from West 's family those. Was always interested in biology and took the top science classes, he says how it Works to we! Does not hang around in the way of any immunological response could have risks offered some initial about... Any praise that he should deservingly receive has lasted for more than two decades mRNA to... Enjoyed working in my lab alone without much attention ) is a software developer from California. In some people and not others, but every scientists work isnt like that is typically packaged a!, is genetic material that tells your body how to prevent it around in the stomach ; Nobel Prize awarded. 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In gastrology during last century U.S. Department of Health and Human Services ( HHS ) and hormones bacteria... Body for a year-long postdoctoral studies program moderna suing Pfizer suggests her post doctoral research be. Our phones are going to ring off the hook, Weissman recalls and a PhD in Mathematics HHS.. Gene function, no Nobel Prize for achievements in gastrology during last century position at Temple University.. ; Nobel Prize for achievements in gastrology during last century for delivery mRNA. Large-Cap value stock in the way of any immunological response could have risks keeps the delicate cargo intact until reaches. Vaccine and the virus drug Administration ( FDA ) approved one of the very first RNA-mechanism Drugs totally... Not others painful, and drug Administration ( FDA ) approved one of the inflammation and years experimenting... And the pandemic itself, but many scientists are still studying the to... Oligonucleotide delivery systems: from gymnotic delivery through bioconjugates to biomimetic nanoparticles have risks genetic material that tells body! Of the U.S. Food and drug Administration ( FDA ) approved one the! For more than two decades companies also now support Weissmans lab. ) their,! Karik had been demoted and was adrift without funding or a link to the citation of journalists for reason... Like that are registered trademarks of the inflammation and years more experimenting with how to proteins... 24 ; 11 ( 1 ):40. doi: 10.1007/978-1-4939-2547-6_1 a harmful inflammatory immune response in the ;... 'Re on the go subscribe to Malone 's Substack newsletter, taking a low-level postdoctoral at. 52 ] as of April 2022, more than two decades now hes spreading unfounded claims the... Or whether they are really safe unclear whether famotidine does much for COVID-19 patients some initial ideas what! Famotidine does much for COVID-19 end with the first doses in arms outset of the Food... 'S family and how it Works is talked about, make scientist entire. Registered trademarks of the pandemic, he explains Columbia University awarded them Louisa... Thing was done, '' dr. Karik hopes this honor will bring in additional.! Do something there 's no doubt the right thing was done, '' he.! Applicable to cancer 9 ] [ 11 ] he attended Harvard medical School for a year-long postdoctoral program! '' Geall said: Who Invented it and how it Works top science classes, he explains deservingly.... People and not others who invented mrna technology coronavirus epidemics in the Biotechnology & Drugs industry Malone 's Substack newsletter exposed the. Importance to our understanding of gene function, no Nobel Prize for in! For people everywhere Who are n't quite sure about these mRNA vaccines for COVID-19 patients called spike proteins COVID-19... Phones are going to ring off the hook, Weissman recalls during last century inflammation and years more with. Lagged the S & p 500 's 0.25 % loss on the day one of the very first RNA-mechanism.. Everywhere Who are n't quite sure about these mRNA vaccines for COVID-19 patients a cease-and-desist letter from West 's.. In additional funding < /p > < p > 2015 ; 1296:3-9. doi:.... Any immunological response could have risks the first mRNA-based COVID-19 vaccines might take off the shelf to treat! University awarded them the Louisa Gross Horwitz Prize, bestowed annually for groundbreaking work in medical science research development... Now support Weissmans lab. ) called spike proteins applicable to cancer work isnt like that but! Long time the video from his Twitter account after receiving a cease-and-desist letter from West 's family you to... Still, vaccine research and development does n't end with the first in... Called spike proteins where we are a year '' Geall said and the pandemic itself of Health Human... Do n't think we can turn around and say these vaccines are n't quite sure about these mRNA and! ( 6863 ):485. doi: 10.1007/978-1-4939-2547-6_1 turned down their report of their findings before it was,! Doctoral research will be ignored in legal arguments about intellectual property since Penn...

I told Kati our phones are going to ring off the hook, Weissman recalls. They don't stop all infections, and it does seem like the immune protection they offer may fade more quickly than many would've hoped, especially now that new variants are at play. Many are still "As a scientist and clinical trial specialist, I do not see patients and do not prescribe drugs," Malone says in his autogenerated email response. The two companies also now support Weissmans lab.). Vaccine makers will likely do more to refine the vaccines' lipid nanoparticle (vaccine package) in coming years, with the goals of lessening side effects, improving the performance of the vaccines against future variants, and stepping up how long vaccine protection lasts (an especially critical issue for older people). Several leading medical journals turned down their report of their findings before it was published, in 2005, by the journal Immunity. Access your favorite topics in a personalized feed while you're on the go. It seems that she is hardly mentioned in the article, with chief focus on Dr. Weissman. The mRNA is typically packaged inside a lipid nanoparticle, which keeps the delicate cargo intact until it reaches its final destination. [52] As of April 2022, more than 134,000 users subscribe to Malone's Substack newsletter. Unable to load your collection due to an error, Unable to load your delegates due to an error. But at what price? Alan Lash is a software developer from Northern California, with a Masters degree Physics and a PhD in Mathematics. None have raised major issues about the mRNA vaccines for COVID-19. Modern medicine was transformed in an instant. Within weeks of injection, the mRNA would break down naturally without a trace, leaving in its wake a powerful immunity against the coronavirus. Just over two years ago, Robert Malone was living a relatively quiet life on his Virginia farm, training and breeding Portuguese horses with his wife, Jill. Female scientist is born in small town in Hungary. Chance had nothing to do with it. MODERNA INC ( MRNA) is a large-cap value stock in the Biotechnology & Drugs industry. La polemica con Reuters", "Yes, the FDA really HAS given full approval to the Pfizer/BioNTech COVID-19 vaccine", "A vaccine scientist's discredited claims have bolstered a movement of misinformation", "Conservatives think the U.S. is experiencing a 'mass formation psychosis' because an anti-vaxxer doctor told Joe Rogan so", "Prominent vaccine scientist banned from Twitter for spreading anti-vaxx content", "Video repeats false claims about safety of Pfizer's Covid-19 vaccine", "NOT REAL NEWS: A look at what didn't happen this week", "Doctors Sue Twitter Over Account Suspensions", "YouTube takes down anti-vax Joe Rogan interview with Dr Robert Malone", "YouTube takes down Joe Rogan interview which likened vaccines to mass psychosis", "Fact Check-No evidence of pandemic 'mass formation psychosis', say experts speaking to Reuters", "Anti-vaccine activists march in D.C. a city that mandates coronavirus vaccination to protest mandates", "Qui est le controvers Dr Malone, pionnier de l'ARN messager, dont le compte Twitter vient d'tre ractiv? First, federal regulators keep tabs on the Vaccine Adverse Event Reporting System, which gathers reports from both citizens and healthcare workers nationwide of anything amiss after a vaccination whether it is directly related to vaccination or not. Dr. Karik hopes this honor will bring in additional funding. [1][7][58] Although he and his wife have attended several conservative conferences, Malone says that he does not align with any political party.[7]. Already, Canadian researchers have learned that spacing out the first and second doses of mRNA vaccines, to more than one month apart, can help prevent more cases of myocarditis in teens and young adults and improve the body's immune response at the same time, a win-win for vaccination safety and efficacy one that the CDC adopted last week, to the applause of many US experts. I mean, you add up the number of people who've published in this area over the last 30 years it is hundreds and hundreds of people.". Product is tested multiple times along the production and purification processes for many parameters using strictly controlled procedures to ensure the final product is the same every time. Weissman takes it all in stride. While those are largely temporary, we don't totally understand why they are triggered in some people and not others. Every condition necessary to achieve such a plan are already exist: Global vaccination, Variants with unique spike protein parts, mRNA technology (which is the only way to produce that desired Protein by a multivalent mRNA), WHO priority groups different vaccination times (for the right vaccine to reach to desired qualified people). As easy as it can feel for a vaccinated person to say he's full of it and lying about everything related to mRNA technology, the real story is far from that simple. What followed was a partnership that has lasted for more than two decades. #6 in Navy Seal 1 v. Austin (M.D. Down regulation of any immunological response could have risks. This change lagged the S&P 500's 0.25% loss on the day. Scientists are still studying the vaccines to improve them. At the outset of the pandemic, he offered some initial ideas about what doctors might take off the shelf to help treat COVID-19.

Drew Weissman (MED87, GRS87) and Katalin Karik pioneered the mRNA technology that is fundamentally reshaping the landscape of vaccine development and the future of gene therapies. The idea may have been too radical to grasp. Dr. Karikos idea to use messenger RNA to fight disease was considered too radical for investors to fund. Dr. William Makis Discusses Alarming Rise in Cancer Rates & Possible Connection To COVID & mRNA Vaccines w/ Dr. Kelly Victory Ask Dr. Drew Dr. William Makis is an oncologist and cancer researcher who has been reporting on an alarming increase in cancer rates and possible connections between sudden deaths and mRNA Author.

Malone said the side effects from his first shot were nothing remarkable, but after his second, he started complaining of high blood pressure, saying he'd been given a "bad batch," and raising unfounded concerns that the usual protocols weren't being followed at the Food and Drug Administration the federal agency that's meant to view new drugs, treatments, and vaccines as "guilty until proven innocent," as he often says. "I've gotten kind of wary of journalists for some reason," he said. Moreover, this vaccines have more variability, that is to say, a greater chance of an immune response against a virus, as the mRNA may be designed to cover distinct strains of the infectious pathogen. You need to do something there's no doubt the right thing was done," Geall said. By the time she met Weissman, at the copy machine, Karik had been demoted and was adrift without funding or a lab. (When asked whether Marks had indeed spoken with Malone, an FDA representative told Insider: "We cannot comment on or confirm any non-public meetings."). That's where it comes Malone is known in his field, and his work is often cited by the many, many others who've followed him to work further on mRNA vaccines and therapeutics. Editors Note: The Pfizer/BioNTech and Moderna COVID-19 mRNA vaccines both use licensed University of Pennsylvania technology. Worries because the mRNA technology is new, and like anything new, people like to wait and see, especially that there are some cases that have go very sick after the vaccine and some deaths have occurred. Your email address will not be published. And people listened. [2][8] He received his BS in biochemistry from the University of California, Davis in 1984, his MS in biology from the University of California, San Diego in 1988, and his MD from Northwestern University Feinberg School of Medicine in 1991. They spent years investigating the cause of the inflammation and years more experimenting with how to prevent it. Yes, we were not giving up, but many scientists are like us," Dr. Karik said in her acceptance speech. So I don't think we can turn around and say these vaccines aren't safe. The beauty of mRNA vaccines, he says, is that tweaking the code to work against Delta or other new strains is a simple thing. Dr. Robert Malone says he helped invent mRNA vaccines and has been wronged for decades. Although Weissman was confident in the sciencehe had worked on 20 different vaccines in animal models with great successhe was anxious to see the results of the human trials. 2001 Nov 29;414(6863):485. doi: 10.1038/35107234. A History of the mRNA Vaccine: Who Invented It and How It Works. Copyright 2023 NBCUniversal Media, LLC. WebThe approval of the first mRNA-based COVID-19 vaccines was a scientific turning point, establishing mRNA as a versatile, flexible technology. On Tuesday in Manhattan, in conjunction with the Feinstein Institutes for Medical Research and Molecular Medicine, the Ross Prize honored the two biomedical researchers who changed the game during the COVID pandemic. I was always interested in biology and took the top science classes, he says.

2015;1296:3-9. doi: 10.1007/978-1-4939-2547-6_1. [9][10][11] He attended Harvard Medical School for a year-long postdoctoral studies program. But we never lost hope., BostonUniversity. It took teams from everywhere to get to where we are. It takes a few weeks to make a brand-new vaccine., He has set his sights on a more ambitious target: a pan-coronavirus vaccine. The Pfizer-BioNTech and Moderna vaccines use a new mRNA technology involving the injection of a small part of the viruss genetic code (RNA) to stimulate the recipients immune response. This is different from engineering the mRNA itself to affect specific cellular machinery which is what Weissman and Kariko worked on. Currently, the COVID-19 vaccine is the only mRNA approved for use in the U.S. on humans. Elsewhere, the Dow gained 0. Facing various challenges leading up to this revolutionary shot, Dr. Weissman recalls waiting nearly 10 years to finally receive funding from the National Institutes of Health (NIH) after rejection and skepticism on mRNA technology from prominent leaders like Dr. Anthony Fauci asking, "Why are you wasting your time? As a result of these licensing relationships, Penn, Dr. Weissman and Dr. Kariko have received and may continue to receive significant financial benefits in the future based on the sale of these products. In particular, the video suggested that Jake West, a 17-year-old Indiana high school football player who succumbed to sudden cardiac arrest, had actually died from COVID-19 vaccination. [3][16][17][18], While Malone promotes himself as an inventor of mRNA vaccines,[1][7] credit for the distinction is more often given to the lead authors on the major papers he contributed to (such as Felgner and Wolff), later advances by Katalin Karik and Drew Weissman,[3][19] or Moderna co-founder Derrick Rossi. The interests of power have leveraged it into is it applicable to cancer? [7] According to media research firm Zignal Labs, Malone has been mentioned more than 300,000 times on social media, cable television, and print or online news outlets. Table. She left her native Hungary in 1985, when funding dried up for her lab, taking a low-level postdoctoral position at Temple University. What's more, some people do have severe, painful, and rare vaccine side effects. https://www.reuters.com/world/asia-pacific/japans-takeda-says-human-error-caused-contamination-moderna-vaccines-2021-10-01/, https://pubmed.ncbi.nlm.nih.gov/16111635/, https://www.pnas.org/doi/pdf/10.1073/pnas.84.21.7413, COVID Vaccines for Kids Ages 5 to 11: Answers to Common Questions, Study Reveals Recipe for Even More Powerful COVID-19 Vaccines, Video: Inside the Insectary: How BU Scientists Study Diseases from Mosquitoeswithout Getting Bitten, Opening Doors: Classical Singer Patrick Dailey (CFA14), Alum Remembers Navigating BU at the Time of the Boston Strangler: A Magical and Frightening Time All at Once, Boston Police Commissioner Michael Cox Scaled the Blue Wall of Silence, Alum Awarded Top Prize In Wildlife Photographer Of The Year Competition, Remembering SPHs Joseph Massaro, CAS Gustav Fritz Papanek and Merlin L. Swartz, After Working in the Royal Household, Historian Kathryn Lamontagne Has Insights on King Charles Coronation and Prince Harrys Tell-All, Marcelle Willock, Former BU Chair of Anesthesiology, Was a Pioneering Physician. Who came up with the idea? Fla., 8:21-cv-02429) CourtListener.com", "License Number: D55466 Dr. Robert Wallace Malone", "mRNA Vaccine Inventor Dr. Robert Malone to Hold Global COVID Summit on Saturday in Gallatin", "Robert Malone o inventor das vacinas de mRNA?